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Lysosomal enzyme activity in liver tissue from patients with renal carcinoma
Author(s) -
Scherstén T.,
Wahlqvist L.,
Johansson LG.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196903)23:3<608::aid-cncr2820230313>3.0.co;2-9
Subject(s) - medicine , enzyme , carcinoma , enzyme assay , kidney , renal carcinoma , pathology , biochemistry , biology
The free and total activities of 4 lysosomal enzymes—acid phosphatase, aryl sulphalase, cathepsin and β‐glucuronidase—were determined in liver tissue obtained as biopsy at operation of 12 patents with malignant tumor of kidney and compared with the corresponding activities in control patients operated on for uncomplicated gallbladder stones. The liver tissue of patients with malignant renal tumor had significantly higher protein content. Both free and total activity of aryl sulphatase, cathepsin and β‐glucuronidase was significantly increased in liver tissue of these patients. The total activity of cathepsin in liver tissue was positively and significantly correlated to the volume of renal tumor. The results do not permit any conclusion about the mechanism for the increase of lysosomal enzyme activity in liver tissue. Two possibilities are discussed.