Premium
Histologic effects of endolymphatic radiotherapy
Author(s) -
Lord Reginald S. A.,
Kinmonth J. B.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196902)23:2<440::aid-cncr2820230219>3.0.co;2-o
Subject(s) - lymph , medicine , lymphatic system , lymph node , pathology , bone marrow , spleen , fibrosis , radiation therapy , radiology
Lipid preparations labelled with 32 p and 131 I were infused directly into lymphatic vessels draining to V x 2 tumor‐involved lymph nodes in the rabbit. The animals were killed from 1 to 250 days later, at which time the target lymph nodes and other viscera were examined. The initial response of the infused lymph nodes was characterized by a rapid necrosis of all cells within the physical range of the isotope. Cellular debris was then removed leving little more than the original fibrous framework of the node. Progressive fibrosis followed, eventually forming a contracted sclerotic mass, unrecognizable as a normal node. The lungs, liver, spleen, bone marrow, kidneys, ureters, and bladder were also examined. No specific effects of radiation were detected in these organs. The technique proved safe for organs while achieving massive oncolysis in the target lymph nodes.