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Fibrosarcoma of bone: a study of 114 cases
Author(s) -
Dahlin David C.,
Ivins John C.
Publication year - 1969
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196901)23:1<35::aid-cncr2820230104>3.0.co;2-v
Subject(s) - fibrosarcoma , medicine , sarcoma , amputation , radiation therapy , bone sarcoma , lesion , pathology , osteosarcoma , radiology , surgery
A study conducted at the Mayo Clinic affirms that fibrosarcoma is a distinctive lesion of bone, although it may be difficult to differentiate from some other tumors, notably fibroblastic osteogenic sarcoma. The 5‐year survival rate of 28.7% in fibrosarcoma is better than that in osteogenic sarcoma (even of the fibroblastic type), so the distinction should probably be maintained. Well‐differentiated fibrosarcomas are associated with an appreciably better prognosis than are the more anaplastic ones. The principles for treatment in fibrosarcoma are similar to those in osteogenic sarcoma because both tumors are radioresistant. When applicable, amputation is usually the preferred treatment. Wide local resection may be successful for some of the smaller and less anaplastic fibrosarcomas of bones of the extremities and has been successful in eradicating tumors at selected other sites, notably the mandible. Radiation therapy is sometimes beneficial. No less than 30% of this total series of fibrosarcomas were secondary to other tumors or related to prior radiation, and the chance of survival after adequate therapy in this group was not significantly different from that of the remainder.