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Antilymphocytic leukemic serum and chemotherapy in the treatment of murine leukemia
Author(s) -
Miller Daniel G.,
Moldovanu Graziella,
Kaplan Alan,
Tocci Salvatore
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196811)22:6<1192::aid-cncr2820220615>3.0.co;2-c
Subject(s) - antiserum , medicine , cyclophosphamide , leukemia , in vivo , chemotherapy , titer , antibody , immunology , concomitant , in vitro , biology , biochemistry , microbiology and biotechnology
Antiserum against L 1210 murine leukemia was prepared in rabbits and goats. Murine antibody titers against such antisera were lower than against normal foreign serum, suggesting an immunosuppressive effect. Additional suppression of antibody formation was obtained by the concomitant use of cyclophosphamide. The antiserum had an equally cytotoxic effect against normal and leukemic lymphocytes in vitro. The antileukemic effect in vivo was demonstrated by a statistically significant but slight prolongation of survival time of leukemia‐bearing mice. The results of therapy with the antileukemic serum were enhanced in some experiments by the incorporation of cyclophoshamide and 6‐mercaptopurine into the treatment schedule.