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Splenic myelosuppressive syndrome. A case report
Author(s) -
Korbitz Bernard C.,
Reiquam C. W.,
Palmer Harold D.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196811)22:6<1185::aid-cncr2820220614>3.0.co;2-7
Subject(s) - medicine , splenectomy , spleen , etiology , bone marrow , haematopoiesis , neutropenia , pathology , hematologic disease , extramedullary hematopoiesis , disease , immunology , surgery , chemotherapy , stem cell , biology , genetics
A patient is presented who exhibited granulocytopenia, thrombocytopenia, splenomegaly and hypoplastic marrow which persisted for 8 years, despite empirical attempts at therapy with corticosteroids and other agents. Following splenectomy, however, the peripheral blood count returned to normal and serial bone marrow biopsies revealed a gradual normalization of the previously hypoplastic bone marrow. Examination of the spleen yielded no evidence to incriminate splenic sequestration of any of the formed elements. The literature pertaining to chronic neutropenia is briefly reviewed and a hypothesis presented regarding the role of the spleen in the etiology of this patient's hematologic disease. The authors believe that this case report lends support to Dameshek's 2 concept of a splenic humoral influence on hematopoiesis.