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Radical radiation therapy and total body irradiation in the treatment of Ewing's Sarcoma
Author(s) -
Millburn Lowell F.,
O'Grady Lois,
Hendrickson Frank R.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196811)22:5<919::aid-cncr2820220504>3.0.co;2-p
Subject(s) - medicine , sarcoma , radiation therapy , ewing's sarcoma , ionizing radiation , total body irradiation , radiology , nuclear medicine , surgery , irradiation , chemotherapy , pathology , physics , nuclear physics , cyclophosphamide
The results presented in the recent literature on the treatment of Ewing's sarcoma are more than encouraging. Radiation therapy has been and remains the treatment of choice in this disease. The concept of irradiating the entire bone of involvement with high doses in short periods of time has only recently been reached. The misinterpreted clinical observation that the rapid response of this tumor to ionizing radiation meant that it could be controlled by low doses has been slow to die. Many authors have advocated including the entire bone in the irradiated volume, yet no reported series states that this was done to all patients treated. In this article the authors present their experience with total body radiation and Ewing's sarcoma in addition to the historical development of this treatment. Particular emphasis is placed on the radiotherapeutic approach to bone tumors and the feasibility of managing patients undergoing total body radiation of this magnitude.