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Clinical radiation pathology as applied to curative radiotherapy
Author(s) -
Rubin Philip,
Casarett George W.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196810)22:4<767::aid-cncr2820220412>3.0.co;2-7
Subject(s) - radiosensitivity , medicine , radiation therapy , pathology , life span , radiobiology , medical physics , radiology , gerontology
The value of radiation pathology in understanding the radiation effects in normal tissues and tumors is stressed in developing curative radiotherapy. A theory of cell radiosensitivity is presented based on cellular proliferation, differentiation and life span. From this base, concepts of tissue and organ radiosensitivity are developed utilizing the knowledge of tissue organization, cell kinetics and microcirculation. Through a series of paradigmatic charts and drawings an attempt is made to explain different clinical manifestations of radiation reactions on the basis of similar histopathologic changes. Possible future directions for radiation research to explore are outlined.