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Bradykininogen levels in Hodgkin's disease
Author(s) -
Eilam Naomi,
Johnson Paul K.,
Johnson Nancy L.,
Creger William P.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196809)22:3<631::aid-cncr2820220319>3.0.co;2-a
Subject(s) - pathogenesis , disease , medicine , inflammation , bradykinin , mediator , immunology , receptor
Patients with active Hodgkin's disease were found to have significantly lower levels of plasma bradykininogen than either normal subjects or those with inactive Hodgkin's disease. While low levels of bradykininogen have not been subjected to metabolic scrutiny in order to evaluate such explanations as depressed manufacture or altered excretion or distribution, the finding could be compatible with increased release of bradykinin, a substance thought to be a chemical mediator of inflammation. Whether heightened bradykinin activity in Hodgkin's disease might be merely one of a number of concomitants of the disease, or more centrally concerned with the pathogenesis of the inflammatory aspects of the disorder, cannot be established at this time. However, this finding serves to emphasize another possibly important variable in the host response in Hodgkin's disease, namely that of the behavior of chemical mediators of inflammation.