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Invasive Hodgkin's disease of brain. Report of two new cases and review of American and European literature with clinical‐pathologic correlations
Author(s) -
Marshall Gerald,
Roessmann Uros,
van den Noort Stanley
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196809)22:3<621::aid-cncr2820220318>3.0.co;2-e
Subject(s) - medicine , pathology , papilledema , disease , cranial nerves , central nervous system , dermatology , anatomy , surgery
A review of American and European literature on cases of Hodgkin's disease invading brain is presented. Two additional cases are reported. An unexpectedly high number of initial complaints are referable to the central nervous system. Common clinical features are lesions of nerve roots with pain and amyotrophy; there are multiple cranial nerve palsies and papilledema. The pattern of involvement consists of widespread meningeal lesions with subsequent invasion of brain substance. Histologic evidence of widespread meningeal involvement may occur without change in the gross appearance.