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Human lymphoblastoid lines from lymph node and spleen
Author(s) -
Levy Jay A.,
Virolainen Martti,
Defendi Vittorio
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196809)22:3<517::aid-cncr2820220305>3.0.co;2-a
Subject(s) - medicine , lymphoblast , spleen , lymph node , cell culture , mycosis fungoides , lymph , biopsy , pathology , immunology , lymphoma , biology , genetics
Two lymphoblastoid cell lines have been established from patients who at the time of the initiation of the cultures did not show evidence of malignant diseases. WI‐L1 line originated from a lymph node biopsy of a patient who later developed a clinical course compatible with mycosis fungoides. WI‐L2 line was established from the spleen of a patient having hereditary spherocytic anemia. The lines were initiated by the organ culture method and then adapted to suspension cultures. The properties of these lines are similar to those derived from Burkitt's or leukemic patients and one (WI‐L1) contains a herpes‐type particle.