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Ultrastructure of Ewing's sarcoma of bone
Author(s) -
Friedman Barry,
Gold Harold
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196808)22:2<307::aid-cncr2820220208>3.0.co;2-f
Subject(s) - cytoplasm , pathology , sarcoma , mesenchymal stem cell , ultrastructure , cell , golgi apparatus , endoplasmic reticulum , biology , microbiology and biotechnology , medicine , biochemistry
An electron‐microscopic examination of Ewing's sarcoma tissue was made in order to: (1) examine the cytoplasm which is not evident by light microscopy and (2) attempt to determine the origin of the Ewing's sarcoma cell. The predominant cell resembles a mesenchymal blast or stem cell in fine structure. The plasma membrane appeared to be a monolayer while the cytoplasm contained few organelles, accounting for their poor visualization by light microscopy. Glycogen granules were seen in the cytoplasm of osmium‐fixed cells. In addition to the principal tumor cells there were others with more dense cytoplasm and nuclei, resembling reticulum cells. The presence of cells intermediate in appearance between principal tumor cells and dark cells suggests a transition from stem cell to mature reticulum cell, the inference being that Ewing's sarcoma is a neoplasm of immature reticulum cells.