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The developmental defects associated with neuroblastoma—etiologic implications
Author(s) -
Sy Wilfrido M.,
Edmonson John H.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196807)22:1<234::aid-cncr2820220127>3.0.co;2-w
Subject(s) - neuroblastoma , syndactyly , medicine , pathology , biology , genetics , anatomy , cell culture
The case of an infant with neuroblastoma syndactyly and rib anomalies is presented. Twenty‐six cases of neuroblastoma have been recorded in which a variety of developmental defects have been found. The possible etiologic implications of the association of developmental defects with neuroblastoma are discussed. The absence generally of familial aggregation of neuroblastoma or of a specific pattern of associated developmental defects is consistent with the hypothesis that most cases of neuroblastoma result from sporadic postzygotic disorders. That germinal mutation may also rarely lead to neuroblastoma is suggested by the existence of four affected siblings in a single report.