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Cytochemical studies of glycogen, neutral mucopolysaccharides and fat in malignant tissues
Author(s) -
Elizalde Adolfo,
Korman Samuel
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196806)21:6<1061::aid-cncr2820210606>3.0.co;2-9
Subject(s) - glycogen , medicine , pathology , adenocarcinoma , plasma cell myeloma , bone marrow , thyroid , cancer
Smears of needle aspirates of tumors and bone marrow from 128 patients with a variety of neoplasms and from seven with lymphadenitis were studied. In addition the bone marrow aspirates of 40 noncancer patients were also investigated. Glycogen was positive in most cases of squamous cell, pancreatic and renal carcinomas and lymphosarcomas. Five of six cases of hypernephroma showed a unique pattern. Approximately half the cells had a high concentration of glycogen and half was essentially free of glycogen. The intercellular substance also had a marked amount of glycogen. Nearly all smears from gastric, colonic and ovarian carcinomas as well as from reticulum cell sarcomas were negative for glycogen. Glycogen was barely perceptible in reactive lymphadenitis. Neutral mucopolysaccharides were positive in most of the smears from gastric, colonic, pancreatic and ovarian adenocarcinoma. Half of the specimens was positive in pulmonary and mammary adenocarcinomas. Fat was present in most of the cases of squamous cell carcinoma, anaplastic carcinoma of the lung, gastric, mammary, ovarian, prostate, thyroid and renal carcinomas, reticulum cell sarcoma and multiple myeloma. The glycogen, NMPS and fat of the bone marrow cells in cancer as well as in noncancer patients were also studied.