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Influence of five anti‐cancer drugs on the induction and growth of experimental mammary cancers: Comparison with ovariectomy
Author(s) -
Douglas Rees E.,
Ross Alan
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196806)21:6<1029::aid-cncr2820210602>3.0.co;2-1
Subject(s) - medicine , methotrexate , cyclophosphamide , methylcholanthrene , vinblastine , thiotepa , drug , cancer , endocrinology , oncology , carcinogen , chemotherapy , pharmacology , biology , genetics
The effects of cyclophosphamide, thiotepa, methotrexate, vinblastine, and 5‐fluorouracil on mammary carcinomas induced in female rats by 3‐methylcholanthrene were assessed. In one factorial experiment a group of rats received drugs concurrently with 3‐methylcholanthrene; a second (delay) group received drugs in the postcarcinogen period during which cancers became palpable. Mortality was less and drug effectiveness greater in the delay group. Methotrexate and 5‐fluorouracil significantly prolonged time of tumor appearance but combination of the two showed a negative interaction. In a second experiment simultaneous administration of drugs and 3‐methylcholanthrene was shown to increase mortality, especially in older rats. Drugs delayed tumor appearance but elicited more tumors than expected in older (relatively resistant) rats. Some rats receiving drugs (but not 3‐methylcholanthrene) developed mammary carcinomas. In a study of the effect on established carcinomas of cyclophosphamide, 5‐fluorouracil, 3‐methylcholanthrene and ovariectomy, ovariectomy elicited more rapid regressions in more tumors. Drug treatment prior to ovariectomy did not affect hormone dependency.