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Induction of remission in childhood leukemia with vincristine and 6‐mercaptopurine and methotrexate. Administration in Sequence after Prednisone
Author(s) -
Sltarz A. L.,
Brubaker C.,
Hartman J.,
Leiken S.,
Murphy M. L.,
Wolff J. A.,
Perrinphd E.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196805)21:5<920::aid-cncr2820210515>3.0.co;2-f
Subject(s) - vincristine , medicine , mercaptopurine , prednisone , methotrexate , complete remission , regimen , leukemia , spontaneous remission , surgery , acute lymphocytic leukemia , gastroenterology , chemotherapy , cyclophosphamide , lymphoblastic leukemia , pathology , alternative medicine
Seventy‐eight children with acute leukemia who had failed to undergo remission with prednisone therapy were treated with vincristine. Those who again failed to respond adequately were treated with combined 6‐mercaptopurine and methotrexate. Seventy patients in the vincristine‐treated group were evaluated and 42 of these (60.0%) had complete or good partial remission. Complete bone marrow remission was achieved in 33 of these subjects (47.1%). Thirty‐three children were entered on the combined 6‐mercaptopurine—methotrexate regimen, all but one of whom were evaluated. Fifteen of 29 patients having an adequate trial (51.7%) attained complete or good partial remissions in this group and complete marrow remission was seen in six (20.7%).