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Effect of coley's toxins and irradiation on the A. Melanoma #3 tumor in the golden hamster
Author(s) -
Donaldson Sarah S.,
Cooper Robert A.,
Fletcher William S.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196805)21:5<805::aid-cncr2820210504>3.0.co;2-9
Subject(s) - medicine , melanoma , radiosensitivity , radiation therapy , toxin , lesion , hamster , cancer research , pathology , microbiology and biotechnology , biology
The effect of the combination of bacterial toxin and x‐ray therapy was studied in the golden hamster using the A. melanoma #3 tumor. The implanted tumor was irradiated with a „tumoricidal” dose of x‐ray therapy in two groups—with and without pretreatment with bacterial toxins. Other groups received smaller doses of irradiation and two groups served as controls receiving either toxin treatment alone or no therapy. Findings revealed that (1) toxin therapy does not affect survival; (2) toxin pretreatment potentiates x‐ray therapy; (3) metastases are not affected; (4) normal tissues show no increased radiosensitivity; (5) toxins plus x‐ray therapy do not affect the prognosis or survival of the host; (6) toxins plus x‐ray therapy show a synergistic effect. This treatment may be useful for lesions which have not metastasized or for control of a symptomatic primary or secondary lesion in the face of incurable metastases.