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Cells in lesions of mycosis fungoides lymphoma following therapy: Changes in number and type
Author(s) -
Waldorf Donald S.,
Ratner Arnold C.,
Van Scott Eugene J.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196802)21:2<264::aid-cncr2820210216>3.0.co;2-1
Subject(s) - mycosis fungoides , medicine , lymphoma , pathology , disease , radiation therapy , dermatology , treatment modality , chemotherapy
The cellular infiltrate in mycosis fungoides lymphoma was evaluated by a quantitative morphologic technique prior to, during, and after therapy with various antilymphoma agents. Prior to therapy plaques of disease differed from tumors in having fewer total cells and fewer atypical cells per unit field. Both types of lesions responded very well to each treatment modality employed with clinical regression occurring in 30 of 32 areas. After therapy there was a marked reduction in the total number of cells and of atypical cells. The number of lymphocytes remained constant. These changes are discussed with reference to their significance to the course of the disease.