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Surface detection of circadian rhythm in 32 P content of cancer of the breast
Author(s) -
Stoll Basil A.,
Burch William M.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196802)21:2<193::aid-cncr2820210206>3.0.co;2-5
Subject(s) - circadian rhythm , rhythm , nocturnal , endogeny , infradian rhythm , period (music) , medicine , human breast , breast cancer , hormone , endocrinology , cancer , ultradian rhythm , physics , acoustics
A recent report of periodicity uptake of 32P in human mammary carcinoma has been confirmed. Whereas previous observations were made with an interstitial counter, in the present series it was demonstrated by a surface detector and an integrated counting system. With this technique, periodicity was shown in nine of the 19 patients examined. Unlike the observation made by Hale (1961) of a 6 to 36 hour periodicity, the cycle was circadian in all nine of the present cases. It showed a close relationship to circadian fluctuation in adjacent skin temperature. A common “biological clock” control could be suggested. The sophisticated technique employed demonstrates that the circadian rhythm in 32P uptake is not sinusoidal in form. It comprises low diurnal and high nocturnal levels with fairly rapid transitions between them. Its persistence in tumors possibly indicates continued response to endogenous hormones.