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Antigenicity of rhabdomyosarcomas induced by nickel sulfide (Ni 3 S 2 )
Author(s) -
Corbeil Lynette B.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196802)21:2<184::aid-cncr2820210204>3.0.co;2-9
Subject(s) - antigenicity , antiserum , antigen , antibody , heterologous , immunofluorescence , stain , microbiology and biotechnology , nickel sulfide , cytoplasm , medicine , virology , pathology , chemistry , sulfide , biology , immunology , staining , biochemistry , organic chemistry , gene
Immunoelectrophoretic analysis of adsorbed heterologous antiserum indicated that rhabdomyosarcomas induced by nickel sulfide gained four to five “tumor‐specific” antigens and lost one to two “muscle‐specific” antigens. Serum from tumor‐bearing and immunized rats contained tumor‐specific antibodies, as shown by the indirect fluorescent antibody technique to stain cultured tumor cells. Antigen appeared to be located in the cytoplasm. Cells from different tumors did not cross‐react significantly but cells from a transplantable tumor did cross‐react with each other through successive generations.