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Adenocarcinoma, adenomas and polyps of the colon: Histochemical study
Author(s) -
Czernobilsky Bernard,
Tsou K.C.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196802)21:2<165::aid-cncr2820210202>3.0.co;2-e
Subject(s) - hyperplastic polyp , adenomatous polyps , adenoma , adenocarcinoma , alkaline phosphatase , medicine , pathology , gastroenterology , acid phosphatase , colonoscopy , biology , enzyme , colorectal cancer , biochemistry , cancer
Acid and alkaline phosphatases, esterase, ATPase and succinic dehydrogenase were studied in colonic lesions. Inflammatory and retention polyps showed normal enzymatic activities. Adenocarcinoma, villous adenoma, adenomatous and hyperplastic polyps demonstrated loss of acid phosphatase, esterase and ATPase. Succinic dehydrogenase was irregularly distributed and showed diminished activity with focal intense reaction in adenocarcinoma, while demonstrating uniform diminution in villous adenoma and atypical areas in adenomatous polyps and hyperplastic polyps. Adenomatous polyps showed intense succinct dehydrogenase activity. Alkaline phosphatase could not be demonstrated in the tissues examined. The lesions were classified according to histochemical patterns. Inflammatory and retention polyps were grouped together. Adenomatous polyps constituted a separate group. Adenocarcinoma formed another division. Villous adenoma, atypical areas in adenomatous polyps and hyperplastic polyps were classified together. Thus the hyperplastic polyp does not appear to be related to either the adenomatous, inflammatory or retention varieties. The significance of the enzymatic similarities of hyperplastic polyps and the potentially invasive colonic lesions must be investigated further.