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Parabiotic transfer of tumor‐specific immunity
Author(s) -
Fisher Jack C.,
Hammond William G.
Publication year - 1968
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196801)21:1<160::aid-cncr2820210124>3.0.co;2-s
Subject(s) - parabiosis , immune system , immunity , medicine , methylcholanthrene , immunology , tumor cells , neoplasm , adenocarcinoma , cellular immunity , cancer research , cancer , biology , pathology , carcinogen , genetics
Using C57 B1/6N female mice and a syngeneic methylcholanthrene‐induced gastric adenocarcinoma, normal and immune mice were joined in parabiotic union for 14 days, separated and subsequently challenged with viable tumor cell suspensions. Results revealed that tumor‐specific immunity could be transferred to normal mice by parabiosis with immune hosts. When tumor‐bearing and immune mice were joined, significant inhibition of tumor growth was observed.