Premium
Experimental radiation pneumonitis. Radiographic and pathologic correlation
Author(s) -
Stetson Charles G.,
Boland John
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196712)20:12<2170::aid-cncr2820201216>3.0.co;2-j
Subject(s) - medicine , radiography , lung , fibrosis , hilum (anatomy) , pneumonitis , radiology , nuclear medicine , radiation pneumonitis , pathology , radiation therapy
A small volume of lung of 36 dogs was subjected to supervoltage irradiation. In half of the animals the hilum of the right lung was exposed by a 3‐field beamdirected technique and in the other half the periphery of the right lower lobe was exposed by a wedge pair technique. The dose levels corresponded to 4200, 5600, 6500, and 8400 rads in 5 weeks. Subsequent radiographs at monthly intervals showed localized consolidation beginning between 3 and 6 months resolving between 6 and 12 months with subsequent fibrosis. Histologic examination showed pleural thickening, inflammatory infiltration, alveolar metaplasia and fibrosis. There was good correlation between radiographic and histologic findings. Higher doses caused more severe reactions. Changes at the periphery occurred earlier and were more severe than at the hilum. Survival in apparent good health after 12 months was obtained at doses of 6500 rads or less.