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Carcinoma of the prostate. Enzyme histochemistry
Author(s) -
Blennerhassett J. B.,
Cohen Richard B.,
Vickery Austin L.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196712)20:12<2133::aid-cncr2820201211>3.0.co;2-t
Subject(s) - prostate , isocitrate dehydrogenase , succinate dehydrogenase , dehydrogenase , epithelium , lactate dehydrogenase , endocrinology , enzyme , medicine , pathology , biochemistry , biology , cancer
The enzyme histochemistry of the prostate gland was investigated in a study of 18 specimens obtained by radical perineal prostatectomy or by transrectal needle biopsy. The enzymes studied were glucose‐6‐phosphate dehydrogenase (G‐6‐PD), isocitrate dehydrogenase (ICD), succinate dehydrogenase (SD), lactate dehydrogenase (LD), β‐hydroxybutyrate dehydrogenase (β‐OHD), dihydroorotate dehydrogenase (DHOD) and triphosphopyridine nucleotide diaphorase (TPNHD). No differences were evident between normal and hyperplastic epithelium. In cases where estrogens had not been administered G‐6‐PD, ICD and TPNHD showed consistent increase in activity in malignant epithelium in comparison with normal and hyperplastic epithelium. There was a marked decrease in activity of all enzymes in tumors from five patients currently receiving estrogen therapy although some areas of all these tumors (particularly invasive tumor in seminal vesicles etc.) retained the “usual” tumor enzyme activity. The implications of these observations are discussed in the light of the relationship of activity of G‐6‐PD and DHOD to nucleic acid synthesis and the relationship of enzyme changes to “hormone responsiveness”.