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Effect of plasma from patients with carcinoma on in vitro lymphocyte transformation
Author(s) -
Silk Mark
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196712)20:12<2088::aid-cncr2820201205>3.0.co;2-1
Subject(s) - in vitro , medicine , lymphocyte , transformation (genetics) , carcinoma , lymphocyte activation , immunology , cancer research , pathology , biology , immune system , biochemistry , t cell , gene
Lymphocytes were grown in culture to which plasma from normal individuals and patients with carcinoma was added; the per cent transformation of lymphocytes measured. Plasma from patients with carcinoma appears to be capable of inhibiting in vitro lymphocyte transformation. The author suggests that this may be one of the factors responsible for the anergy that occurs in these patients and may influence tumor growth.