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Deoxyribonucleic acid content of presumed precursors of endometrial carcinoma
Author(s) -
Wagner Dieter,
Richart Ralph M.,
Terner Jacob Y.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196712)20:12<2067::aid-cncr2820201203>3.0.co;2-c
Subject(s) - feulgen stain , pathology , carcinoma , adenocarcinoma , endometrium , hyperplasia , biology , atypical adenomatous hyperplasia , dna , ploidy , epithelioma , adenoma , endometrial hyperplasia , adenomatous polyps , medicine , cancer , staining , endocrinology , genetics , colorectal cancer , colonoscopy , gene
Microspectrophotometric measurements of Feulgen‐stained gland cell nuclei were carried out in 16 cases of presumed precursors (six cystic glandular hyperplasias, ten adenomatous hyperplasias) and six adenocarcinomas of the endometrium. In all cases of cystic glandular hyperplasia a diploid to tetraploid DNA‐distribution was found which was indistinguishable from that of a normal proliferating epithelium. The same diploid to tetraploid DNA distribution was found in eight of the ten adenomatous hyperplasias. Only two cases of adenomatous hyperplasia had an aneuploid DNA‐distribution pattern and this pattern was similar to that of the invasive carcinomas. In both of these aneupolid hyperplasias there were two different types of glands which could be distinguished by their cytomorphology. The six cases of adenocarcinoma of the endometrium had aneuploid DNA‐distributions. Since every group of precursor lesions in other organs studied by microspectrophotometry have been reported to have aneuploid DNA‐distribution patterns, the results of this study suggest that most of the lesions now diagnosed as precursors of endometrial carcinoma either deviate from the pattern of other epithelia or that the morphologic criteria which traditionally are used in the diagnosis of these lesions are insufficiently precise.