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Shifts in body fluids during radical surgery
Author(s) -
Hoye Robert C.,
Ketcham Alfred S.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196711)20:11<1827::aid-cncr2820201104>3.0.co;2-w
Subject(s) - medicine , extracellular fluid , fluid compartments , interstitial fluid , thoracic duct , albumin , intravascular volume status , lymph , blood volume , cancer surgery , surgery , body water , anesthesia , extracellular , cancer , pathology , hemodynamics , body weight , chemistry , biochemistry
Studies measuring volume of total red cells, plasma and extracellular fluid in patients undergoing extensive surgery in the treatment of cancer are reviewed. These studies reveal the need to closely monitor operative blood loss to avoid a postoperative deficit of total red cell volume. In addition, they demonstrate that during surgery there develops a disproportionate deficit of plasma volume, a decrease in the total circulating protein and a contraction of the volume of extracellular fluid. By measurement of thoracic duct lymph flow, a deficiency in the movement of fluid and albumin from the interstitial fluid compartment to the intravascular compartment during surgery is demonstrated. Throughout these studies the close monitoring of the central venous pressure and urine flow are invaluable clinical aids in determining the quantity and rate of volume replacement.