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Cancer, heredity and genetic counseling. Xeroderma pigmentosum
Author(s) -
Lynch Henry T.,
Anderson David E.,
Krush Anne J.,
Mukerjee Debdas
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196710)20:10<1796::aid-cncr2820201031>3.0.co;2-5
Subject(s) - xeroderma pigmentosum , heredity , medicine , genetic counseling , sibling , cancer , genetic disorder , hereditary diseases , genetics , psychiatry , developmental psychology , pathology , psychology , biology , disease , dna damage , dna
Cancer control can be improved through the application of knowledge of the hereditary aspects of certain malignant and premalignant disorders. A concrete example of the effectiveness of the application of genetic knowledge has been demonstrated by study of a family wherein five of seven siblings manifested xeroderma pigmentosum. Knowledge of the hereditary aspects of this disorder and its discovery in one sibling led to the immediate detection of the disorder in other siblings. In turn, preventive measures were instituted toward the avoidance of exposure to the carcinogenic effects of sunlight. Genetic counseling alleviated anxiety and major misconceptions among the family members concerning the hereditary aspects of this disorder.