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Transitional cloacogenic carcinoma of the anal canal. Clinicopathologic study of three hundred seventy‐three cases
Author(s) -
Klotz Roy G.,
Pamukcoglu Thomas,
Souilliard Donald H.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196710)20:10<1727::aid-cncr2820201024>3.0.co;2-1
Subject(s) - medicine , pathological , lesion , metastasis , carcinoma , distant metastasis , survival rate , adenoid cystic carcinoma , perineural invasion , anal canal , surgery , pathology , rectum , cancer
The clinical and pathological features of 373 transitional cloacogenic carcinomas are presented. This tumor accounts for 2.7% of anorectal neoplasms, occurs twice as often in women and is more prevalent at ages 60 to 70. The majority of the lesions show identical gross appearance to common rectal neoplasms. A small group presented no intraluminal lesion, infiltrated the bowel wall and created difficulty with early diagnosis. A histologic classification was devised that appears to correlate well with prognosis. Rare patterns such as “oat cell,” mucoepidermoid and adenoid cystic carcinomas were recognized as variants. Lymph node metastasis was present at surgery in one third of the cases. Recurrences were common. Metastasis occurred in 19% of cases. Wide abdominal perineal resection produced a cure rate of 50%. Additional posterior vaginectomy is recommended for anterior lesions. The over‐all cure rate was 47%. The average survival time was 19.7 months without, and 27.8 months with, some form of treatment.