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Action of methotrexate on metabolism of lipids and carbohydrates of the perfused isolated liver
Author(s) -
Lemberg A.,
Daunas J. A.,
Brodoff B. B.,
Penhos J. C.,
Sodero E. C.,
White R.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196710)20:10<1668::aid-cncr2820201015>3.0.co;2-w
Subject(s) - ketone bodies , methotrexate , glycogen , endocrinology , medicine , urea , cholesterol , metabolism , lipid metabolism , chemistry , biochemistry
Liver obtained from fed rats was perfused with blood from fasted rats with and without the addition of methotrexate for 90 min. Addition of methotrexate (MTX) produced a greater increase in the levels of ketone bodies and urea. The glycogen content of the liver and glucose level and level of nonesterified fatty acids in the perfusate decreased when MTX was added. Levels of triglycerides, phospholipids, cholesterol esters and free cholesterol also decreased in the perfusate when MTX was added but after 60 min they tended to return to initial levels.