Premium
Apparent antagonism of vaccinia and wart viruses. Preliminary report on virus virus in the tumor battle
Author(s) -
McGee Andrew R.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196710)20:10<1647::aid-cncr2820201011>3.0.co;2-c
Subject(s) - vaccinia , smallpox , medicine , inoculation , virus , virology , local reaction , vaccination , smallpox vaccine , antagonism , dermis , poxviridae , interferon , immunology , biology , pathology , biochemistry , receptor , gene , recombinant dna
One hundred sixty‐five warts involving 60 patients were inoculated with small‐pox vaccine or variously heat‐attenuated forms of this. One hundred sixty‐four warts showed varying degrees of local reaction then disappeared leaving no scar. Prior recent vaccination or vaccination via inoculation of the wart caused some difference in subsequent reactions in a small percentage of cases. Several biological sera and other materials were utilized, but with no comparable wart disappearance. The cellular reaction is predominantly lymphocytic and almost completely limited to the dermis layer. The possibility of an interviral antagonism arises‐perhaps through stimulation of interferon production or its local histological retention or both. In any case the greater percentage of warts, “the only known virus‐caused tumor in humans” regress and disappear when they are directly inoculated with smallpox vaccine or certain heat‐attenuated viable forms of this.