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Effect of colostomy on experimentally produced neoplasms of the colon of the rat
Author(s) -
Navarrete Antonio,
Spjut Harlan J.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196709)20:9<1466::aid-cncr2820200913>3.0.co;2-d
Subject(s) - medicine , colostomy , hyperplasia , anus , lesion , distal colon , gastroenterology , adenomatous polyps , subcutaneous injection , carcinoma , rectal carcinoma , pathology , surgery , colorectal cancer , colonoscopy , cancer
As a means of determining the effect of the fecal stream in the pathogenesis of experimentally produced colonic tumors in Wistar strain rats, simple colostomies were performed in the left colon of 57 female rats at approximately 4 cm above the anus. Fifty‐four rats received daily subcutaneous injections, 5 days per week, of the carcinogen 3:2'dimethyl‐4‐aminodiphenyl at a dosage of 2 mg/day/100 Gm body weight. Of the 54 rats, 17 (31.4%) developed either hyperplasia, adenomatous polyps or carcinoma of the large bowel proximal to the colostomy site. None of the 54 rats developed any lesion distal to the colostomy. None of the three control rats with colostomies developed any kind of tumor. Of the colonic lesions that developed, 12 were hyperplasias, 12 were adenomatous polyps and four were carcinomas. All hyperplasia developed at colostomy edge. Diversion of the fecal stream prevents development of colonic neoplasms in Wistar rats in this experimental situation.