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Maturation of ganglioneuroblastoma to ganglioneuroma
Author(s) -
Dyke Peter C.,
Mulkey David A.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196708)20:8<1343::aid-cncr2820200819>3.0.co;2-g
Subject(s) - ganglioneuroblastoma , neuroblast , ganglioneuroma , ganglion , medicine , neuroblastoma , pathology , neuroscience , anatomy , biology , cell culture , genetics , neurogenesis
A case of ganglioneuroblastoma in a 10‐month infant maturing over a 7‐year period to ganglioneuroma is reported. The four previously recorded cases are reviewed. Possible mechanisms involved may include differentiation of neuroblasts to mature ganglion cells by the influence of naturally occurring organizers, x‐ray initiation of normal cell differentiation, destruction of susceptible neoplastic cells by irradiation with survival of resistent ganglion cells or inhibition of a nerve growth factor stimulating neuroblast proliferation.