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Chromosome analysis of solid tumors. I. Twenty‐eight nonepithelial tumors
Author(s) -
Miles Charles P.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196708)20:8<1253::aid-cncr2820200810>3.0.co;2-8
Subject(s) - karyotype , ploidy , lymph , pathology , chromosome , cytogenetics , biology , medicine , genetics , gene
Abstract Of 25 nonepithelial solid cancers at least two appeared to have classically diploid stemlines. Of aneuploid tumors a few showed the same karyotype in every cell whereas other tumors showed unequivocal karyotype variation from cell to cell. One tumor contained a stemline marker apparently identical with one previously observed in Burkitt's lymphosarcoma. A number of tumors exhibited prominent secondary constriction patterns. Occasional cells showed broken chromosomes and multiradial forms. Two of three lymph nodes, diagnosed histologically as hyperplastic lymph nodes, showed classically diploid cells. A third showed unequivocal chromosome abnormalities.