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Chromosomes and causation of human cancer and leukemia. III. Karyotypes of cancerous effusions
Author(s) -
Sandberg Avery A.,
Yamada Kiyomi,
Kikuchi Yasumoto,
Takagi Nobuo
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196707)20:7<1099::aid-cncr2820200713>3.0.co;2-r
Subject(s) - karyotype , chromosome , cancer , pathology , chromosome instability , biology , medicine , genetics , gene
Abstract Karyotypic findings in 27 cancerous effusions have been presented and the data on all other published effusions summarized. Cancerous effusions are characterized by a wide range of modal chromosomal number, ranging from severe hypodiploidy (35) to more than 100 chromosomes. The karyotypes of such effusions reveal an extremely diversified picture with no two effusions having identical or similar karyotypes. Marker chromosomes were present in the preponderant number of the effusions but their frequency, number and size did not appear to be related to the total chromosome number of the cells. Stability of the karyotypes is indicated by the persistence of the chromosome constitution for a period of time, the reappearance of identical karyotypes when an effusion recurred after therapy and the similarity of the karyotypes in effusions of different location.