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Cancer, chromosomes and congenital abnormalities
Author(s) -
Dumars K. W.,
Kitzmiller Nancy,
Gaskill Catherine
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196706)20:6<1006::aid-cncr2820200611>3.0.co;2-l
Subject(s) - karyotype , cancer , medicine , buccal swab , chromosome , fetus , pathology , cytogenetics , genetics , biology , pregnancy , gene
The frequently described coexistence of cancer and congenital abnormalities prompted this genetic and cytogenetic investigation of a group of cancer patients. Pedigree analysis, buccal smear and chromosome karyotyping were completed upon 53 patients. Pedigree analysis revealed a statistically significant familial coexistence of fetal wastage and carcinoma. Chromosome karyotyping completed upon peripheral blood leukocytes revealed a greater than expected incidence of chromosomal abnormalities. Two of the 34 patients who were affected with cancer had a history of increased fetal wastage and karyotyping revealed an XO/XX (45/46) mosaicism. Because of the small sample, definite conclusions are not possible; however, the study suggests an increased susceptibility to cancer in individuals with certain chromosome abnormalities. Further investigation seems warranted.