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Studies on bleomycin
Author(s) -
Umezawa Hamao,
Ishizuka Masaaki,
Maeda Kenji,
Takeuchi Tomio
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:5<891::aid-cncr2820200550>3.0.co;2-v
Subject(s) - bleomycin , medicine , sarcoma , inflammation , kidney , cancer , hela , lung , skin cancer , pharmacology , pathology , chemotherapy , biochemistry , biology , cell
Bleomycin A, which is a complex of water‐soluble peptides produced by a Streptomyces, inhibits DNA synthesis in intact cells of E. coli and HeLa cells and also inhibits Ehrlich carcinoma and Sarcoma 180. When it is injected, it distributes in lung and skin at higher concentration than in blood and kidney. In dogs a large dose caused liver damage which was reversible but, when a lower dose was injected twice weekly, toxic signs appeared; the signs—inflammation of the foot pad and loss of hair—disappeared after cessation of the injection. It gave curative effect on a skin cancer in a dog. The authors conclude that the effect on skin cancer was due to the high concentration in skin.