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Treatment of inoperable cancer of the liver by intra‐arterial radioactive isotopes and chemotherapy
Author(s) -
Ariel Irving M.,
Pack George T.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:5<793::aid-cncr2820200534>3.0.co;2-i
Subject(s) - medicine , chemotherapy , cancer , liver parenchyma , methotrexate , liver cancer , nuclear medicine , surgery , oncology
One hundred eighteen patients were treated. Of 22 patients given cancer chemotherapeutic drugs alone (methotrexate and 5‐FU), 27% showed objective responses and 59% subjective responses; the average duration of life was 3.9 months. Of 37 patients treated with radioactive isotopes alone ( 90 Y radiating microspheres), objective responses were observed in 32% and subjective responses in 54%; the average duration of life was 4.6 months, 4 patients still are alive at 4 to 18 months. Of 59 patients treated by a combination of cancer chemotherapy and 90 Y microspheres, 47% showed objective responses and 61% subjective responses; the average duration of life was 5.6 months and 4 patients still are alive at 5 to 36 months. In the selection of suitable patients for treatment, hepatic gammascanning has been useful, particularly the combined scans utilizing 131 iodine rose bengal and 198 gold, for determining the gross anatomic extent of cancerous hepatic involvement and the status of the noninvolved hepatic parenchyma.