Premium
Relationship between viral neurotropism and oncolysis. II. Study of influenza virus
Author(s) -
Cassel William A.,
Garrett R. Earl
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:3<440::aid-cncr2820200311>3.0.co;2-r
Subject(s) - oncolytic virus , virology , virus , medicine , virotherapy , influenza a virus , biology , pathology
The WS, type A influenza virus was employed in a study of viral neurotropism and viral oncolysis. The original virus would not multiply in the Ehrlich ascites tumor of the mouse. After it was adapted to full neurovirulence in mice, and at the same time became neurovirulent for other animal hosts, it acquired high oncolytic activity against the tumor. These studies show a distinct correlation between viral neurotropism and oncolysis and suggest some as yet undetermined similarity between neoplastic and nervous tissues. The findings are of significance in considering the application of viruses to human cancers.