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Cytologic studies of enzymes in malignant tissues
Author(s) -
Elizalde Adolfo,
Miller Sherwood P.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:3<423::aid-cncr2820200309>3.0.co;2-y
Subject(s) - pathology , enzyme , sarcoma , medicine , metastatic carcinoma , bone marrow , esterase , aminopeptidase , alkaline phosphatase , carcinoma , biology , biochemistry , leucine , amino acid
The techniques of enzyme cytochemistry have been applied to a study of aspirated and smeared malignant cells and to bone marrow cells. Analysis of the enzyme activity of cells from 240 specimens was carried out. By determining characteristic enzyme activity patterns with 4 enzymes, namely acid and alkaline phosphatase, aminopeptidase and nonspecific esterase, it has been possible to derive patterns for a number of tumors which can aid in the diagnosis of the primary site of origin of metastatic lesions. Distinction between anaplastic carcinomas of some types and lymphoreticular sarcoma is possible on the basis of enzyme studies. Similar distinctions appear to be true for lung and genitourinary tract carcinomas but it was not feasible to determine a general method to distinguish all anaplastic carcinoma from sarcoma. Further study of the diagnostic value of this technique appears to be warranted.