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Failure of low molecular weight dextrans to alter the frequency of lung metastasis. Report on the V2 carcinoma of the rabbit
Author(s) -
Wood Sumner,
Baker R. Robinson,
Johnson Jo H.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:2<281::aid-cncr2820200215>3.0.co;2-k
Subject(s) - dextran , medicine , metastasis , carcinoma , lung , rabbit (cipher) , pathology , cancer research , cancer , biology , biochemistry , statistics , mathematics
Three fractions of low molecular weight dextran (10,000, 40,000 and 70,000) were administered intravenously to Laboratory Lop rabbits before or after intravenous inoculation of ascitic V2 carcinoma cells. The frequency of pulmonary metastases was unaltered by dextran treatment. No extrapulmonary tumor was found in any instance. These findings are discussed in relation to the studies of other investigators and the need for additional experiments employing a variety of tumors and hosts is emphasized.