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“Anaplasia Clinic”. Aid in the diagnosis and treatment of pre‐invasive cervical lesions
Author(s) -
Kramer William M.,
Kay Saul
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:2<202::aid-cncr2820200205>3.0.co;2-q
Subject(s) - anaplasia , medicine , biopsy , cytology , cauterization , cervical cancer , cytopathology , carcinoma in situ , pathology , cancer , carcinoma
A specialized “Anaplasia Clinic” has been of value in evaluating women with abnormal vaginal cytology and no obvious invasive cervical lesion. Using cytology, colpomicroscopy and biopsy as preliminary diagnostic tools, 163 cases of anaplasia, 75 of carcinoma in situ and 8 of invasive cancer have been detected from 339 referrals. Of the patients with biopsy‐proved lesions 89% were in the child‐bearing age group. Three instances of progression from anaplasia to carcinoma in situ have occurred in untreated patients. Biopsy alone produced cytologic regression in 50 of 80 anaplasia cases. Biopsy strongly influences the natural history of anaplasia. Cauterization was effective in causing regression in 17 of 28 cases with persistent abnormalities on smear following biopsy and would appear to be an effective form of therapy for anaplasia.