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Erythroleukemic phase of mouse myeloproliferative syndrome
Author(s) -
Albert S.,
Wolf Paul L.,
Pryjma I.,
Vazquez J.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:1<40::aid-cncr2820200107>3.0.co;2-k
Subject(s) - pathology , spleen , haematopoiesis , bone marrow , medicine , leukemia , myeloid , kidney , myeloid leukemia , immunology , biology , stem cell , genetics
Smears were made of blood and cell suspensions of thymus, spleen, bone marrow, left axillary lymph node, liver, kidney and brain of mice with spontaneous leukemia. They were stained either with Leishman's stain or specifically for hemoglobin with Ralph's stain. The blood and hematopoietic organs from mice with virus‐induced leukemia (Stansly, 1963) were also examined. The presence of large numbers of immature megaloblastoid cells and maturing normoblasts in the hematopoietic organs and the extensive infiltration of these cells into the other organs emphasize the erythroleukemic nature of the disease. The presence of immature myeloid elements in many of the smears suggests that the erythroleukemia is part of a myeloproliferative syndrome.