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Chromosome polyploidization in human leukocyte cultures treated with streptonigrin and cyclophosphamide
Author(s) -
Nasjleti Carlos E.,
Spencer Herbert H.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:1<31::aid-cncr2820200105>3.0.co;2-o
Subject(s) - endoreduplication , cyclophosphamide , polyploid , mitosis , chromosome , in vitro , in vivo , leukemia , chromatid , cancer research , biology , haematopoiesis , medicine , chemotherapy , ploidy , immunology , genetics , stem cell , gene
Treatment of cultured human peripheral blood leukocytes with streptonigrin or cyclophosphamide resulted in morphologic chromosomal changes, as well as polyploid and endoreduplicated mitoses. Polyploidy was present in 11% of cells treated with streptonigrin and in 15% of cells treated with cyclophosphamide. These findings, together with recent data showing polyploidization in normal human leukocytes induced in vivo and in vitro with chemotherapeutic agents and ionizing radiations, suggest that polyploidy and endoreduplication of chromosomes as reported in acute leukemia, might to a large extent be the result of concomitantly administered therapy.