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Trauma and the localization of tumor cells
Author(s) -
Fisher Bernard,
Fisher Edwin R.,
Feduska Nicholas
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:1<23::aid-cncr2820200103>3.0.co;2-p
Subject(s) - medicine , hindlimb , aorta , tumor cells , cell , pathology , anatomy , cancer research , biology , genetics
Injection of 51 Cr labeled Walker tumor cells either intravenously or via the aorta into normal rats or those subjected to mechanical, chemical or surgical trauma of a hind limb resulted in (a) equal distribution of cells to both hind legs when neither was traumatized; (b) a lodgement of a greater number of cells in legs subjected to either of the three types of trauma than in the untraumatized extremity of the same animal; (c) a failure of adequate heparinization to alter cell localization at sites of trauma; (d) no difference in tumor cell localization between normal limbs of control or traumatized animals, minimizing the roll of stress or other systemic factors. It is concluded that increased numbers of tumor cells lodge at sites of trauma and may well be the reason for the observed augmented metastases.