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Choriocarcinoma in the Near East. Consanguinity as a possible etiologic factor
Author(s) -
Iliya Fawzi A.,
Williamson Susan,
Azar Henry A.
Publication year - 1967
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(1967)20:1<144::aid-cncr2820200120>3.0.co;2-1
Subject(s) - choriocarcinoma , consanguinity , medicine , etiology , incidence (geometry) , gynecology , obstetrics , pediatrics , pathology , physics , optics
Epidemiologic and histologic data pertaining to 30 consecutive cases of choriocarcinoma and chorioadenoma destruens in the Near East lend support to the hypothesis that choriocarcinoma is a form of successful homotransplant and the higher incidence of trophoblastic growths in certain parts of the world seems to be favored by endogamous marital customs and “inbreeding.” That consanguinity plays an important role in the etiology of choriocarcinoma and related growths needs to be proven by extensive blood group surveys and other immunological studies in communities where hydatidiform moles and choriocarcinoma are relatively prevalent.