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Fine structure of hemangiopericytoma and hemangio‐endothelioma
Author(s) -
Ramsey Helen J.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196612)19:12<2005::aid-cncr2820191227>3.0.co;2-x
Subject(s) - hemangiopericytoma , cytoplasm , pathology , extracellular matrix , anatomy , extracellular , tumor cells , endothelium , pericyte , biology , medicine , microbiology and biotechnology , endothelial stem cell , cancer research , biochemistry , in vitro , endocrinology
Two vascular tumors of the nervous system, hemangiopericytoma and hemangio‐endothelioma, were readily distinguishable from each other on the basis of their fine structural characteristics. In hemangiopericytoma the exaggerated vasculature was lined with a single layer of cells showing only minor departures from normal endothelium. The tumor cells were closely crowded and cytologically unspecialized, bearing no processes. They sometimes contained osmiophilic particles. Extracellular material occurred around blood vessels and in narrow trabeculae separating the cells into groups. In hemangio‐endothelioma abnormal endothelial cells often were voluminous and showed irregular borders with many fine processes and cytoplasmic vesicles. They tended to lose their proper relation to vascular channels. The cells making up the masses between vessels were variable, scattered and irregular. A few had fibrillar cytoplasm. They were set in an extensive matrix of extracellular material. The few foam cells present contained amorphous lipid inclusions.