Premium
Radiation‐induced neoplasms following curative therapy for retinoblastoma
Author(s) -
Soloway Henry B.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196612)19:12<1984::aid-cncr2820191225>3.0.co;2-8
Subject(s) - medicine , retinoblastoma , radiation therapy , skull , radiology , surgery , biochemistry , chemistry , gene
Twenty‐two cases of radiation induced neoplasms following curative therapy for retinoblastoma are reviewed, and three new cases are reported. Twenty‐four of the 25 growths were malignant, and most were of the osteogenic series and its variants. The young age of the patients at the time of radiotherapy had no apparent effect upon the length of the latent interval, as persons receiving radiotherapy in adulthood had similar latent periods preceding the development of similar tumors. The prognosis of these tumors was exceptionally poor, in part due to the large proportion of sarcomas and also due to the proximity of the tumors to the deep structures of the face and base of the skull.