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Comparative study of bone marrow aspiration and biopsy in patients with neoplastic disease
Author(s) -
Grann Victor,
Pool John L.,
Mayer Klaus
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196612)19:12<1898::aid-cncr2820191217>3.0.co;2-u
Subject(s) - medicine , myelofibrosis , biopsy , lymphoma , bone marrow , sarcoma , aspiration biopsy , aplastic anemia , radiology , pathology , fine needle aspiration
The specific application of aspiration and biopsy are evaluated by a comparative study since both are uncomplicated procedures and may be performed simultaneously through a single skin incision. Following aspiration, biopsy was performed at the same site with the Westerman‐Jensen modified Silverman needle. During the period of study (1961 to 1965) 239 conjoint aspirations and biopsies were obtained from 225 cases at Memorial Hospital. The results of aspiration and biopsy were complementary in patients with carcinoma and malignant lymphoma. The 2 techniques were of equal value in cases of leukemia but biopsy alone was of value in diagnosing Hodgkin's disease and myelofibrosis. Neither method was very helpful in patients with reticulum cell sarcoma. An additional study showed that the observers could not predict marrow cellularity from aspirated material. The authors conclude that aspiration is the most effective method for studying cellular morphology. Biopsy, on the other hand, should be used to assess marrow cellularity and to diagnose cases of aplastic anemia metabolic bone disease, myelofibrosis and granulomatous involvement such as Hodgkin's disease. The 2 techniques should be combined in patients with suspected carcinoma or malignant lymphoma.