Premium
Chromosomes and causation of human cancer and leukemia: I. Karyotypic diversity in a single cancer
Author(s) -
Sandberg Avery A.,
Yamada Kiyomi
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196612)19:12<1869::aid-cncr2820191214>3.0.co;2-2
Subject(s) - karyotype , cancer , chromosome , biology , genetics , leukemia , pathology , medicine , gene
The chromosome constitution of a single cancerous effusion has been studied in detail. Variation in the modal number was encountered at different times of examination of the cells, the appearance of a new modal number being due to cells previously observed in the fluid. Diversity of the karyotypes, even within a group of cells with the same chromosome number, was particularly striking. During the last examination 2 large marker chromosomes were present in over 90% of the cells; these markers were present less frequently on previous examinations. The findings of this study indicate the variability in the karyotypic picture within a single cancer and the process of karyotypic selection occurring within it.