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Megakaryocytes in blood and extramedullary hematopoiesis: Occurrence in hamsters with grafted tumors
Author(s) -
Traykovich Vera,
Rivière Marcel R.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196611)19:11<1717::aid-cncr2820191141>3.0.co;2-r
Subject(s) - haematopoiesis , medicine , megakaryocyte , pathology , spleen , myeloid , extramedullary hematopoiesis , cd34 , sarcoma , hamster , cancer , lymphatic system , precursor cell , mesocricetus , cancer research , immunology , biology , cell , stem cell , genetics
In the course of the study of cancer cells in the blood stream of hamsters with grafted tumors, different forms of megakaryocytes were observed. The morphology and occurrence of these cells are presented. The cells of the megakaryocyte line can be easily mistaken for tumor cells, especially the uncommon form. A correlation was found between an increase of megakaryocytes, including their atypical forms, and the occurrence of an extramedullary reaction. This reaction was present in 65 of 102 hamsters with polymorphous metastatic sarcoma. Myeloid reaction was observed more frequently in the liver than in the spleen or lymphatic nodes and in animals with metastases than in those with none. This reaction is not characteristic for malignant diseases and its significance is discussed.